Document 1839
 DOCN  M94A1839
 TI    Between gender comparative dynamics of biological markers of HIV disease
       progression.
 DT    9412
 AU    de Vincenzi I; Jadand C; Deveau C; Bucquet D; European Centre for the
       Epidemiological Monitoring of AIDS,; Saint-Maurice, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):44 (abstract no. 151C). Unique
       Identifier : AIDSLINE ICA10/94370736
 AB    OBJECTIVE: To compare the dynamics of biological markers of disease
       progression in HIV infected males and females. METHODS: Since 1988,
       non-haemophiliac asymptomatic patients for whom the 1st HIV+ test was
       not older than 12 months and patients for whom the date of infection was
       known were enrolled in the French cohort SEROCO and followed-up. Mean
       lymphocyte (absolute T4 counts, %T4, T4/T8) and type A Immunoglobulin
       (IgA) levels were compared between males and females at 12, 24, 36, 48
       and 60 months after infection for subjects with a date of infection that
       could be estimated at +/- 1 year (Student t test). RESULTS: Significant
       differences between males (M) and females (F) were found up to 60 months
       after infection. These differences are not explained by age at
       infection, route of infection, centre of enrolment, and time between
       infection and inclusion in the cohort. A comparison of the prognostic
       value of these markers will be presented. TABULAR DATA, SEE ABSTRACT
       VOLUME. CONCLUSION: These results are in favour of less severe
       immunological disorders in women compared to men in the first years of
       infection. It is also possible that immunological markers do not have
       the same prognostic value in men and women. Such differences should be
       clarified for the use of these markers in clinical trials including men
       and women.
 DE    Biological Markers/BLOOD  Cohort Studies  Comparative Study  CD4-CD8
       Ratio  Female  Follow-Up Studies  France/EPIDEMIOLOGY  Human  HIV
       Infections/*BLOOD/EPIDEMIOLOGY/*IMMUNOLOGY  IgA/BLOOD  Leukocyte Count
       Male  Prognosis  Sex Characteristics  Time Factors  T4 Lymphocytes
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).